Mast Cell Activation Overview

Mast cells are immune cells that release histamine and are involved in allergic reactions. They are absolutely necessary to our immune system, but can overreact when triggered by stressors including infections and inflammation.

Histamine is a substance that acts like an alarm system in our bodies and signals immune cells to fight off bacteria, infection, viruses and more. Excess histamine within our body may cause an oversensitivity leading to histamine intolerance and Mast Cell Activation Syndrome (MCAS).

Symptoms of Mast Cell Activation Syndrome are multi-systemic and can include:

  • Anxiety

  • Depression

  • Nasal congestion

  • Headaches

  • Head pressure

  • Skin itching

  • Hives

  • Fatigue

  • Heart palpitations

  • Joint pain

  • Gastrointestinal Issues like abdominal pain, diarrhea, bloating, nausea, vomiting

Conditions Mast Cell Activation Syndrome may be related to include:

  • Allergies

  • Asthma

  • Migraines

  • Leaky Gut Syndrome

  • Chronic Hives

  • Chronic Inflammatory Response Syndrome

  • Fibromyalgia

  • Interstitial Cystitis

  • Gastroesophageal Reflux (GERD)

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